199 Biotechnologies
Reprogramming healthspan
We build therapies that address cancer and aging at their common source - epigenetic damage. Instead of destroying cells, we redirect them back to healthier programs.
Lead Program
Cancer Reprogramming
Diagnostics
AgeQuant Platform
At a glance
Context
The dual crisis we face
Cancer remains intractable at the aggressive end, while aging accelerates across populations. Both are driven by epigenetic damage that locks cells into destructive programs.
Glioblastoma remains among the most lethal cancers.
Global aging is accelerating across every region.
Healthcare systems are strained by multi-morbidity.
Our insight
Cells are not broken - they are misprogrammed
By rewriting epigenetic instructions, we can restore healthy function without destroying tissue. That shift unlocks a new class of therapies that are less toxic, more durable, and measurable over time.
Principles
- Epigenetic reset: brief exposure to reprogramming factors can restore youthful cellular function.
- Precision targeting: cancer and senescent cells are addressed while healthy tissue remains intact.
- Measurable impact: interventions are tied to clear biomarker shifts and functional outcomes.
Programs
Three programs, one mission
Each program attacks aging and disease from a different angle, creating a comprehensive platform for healthspan extension.
Partial Reprogramming
Cancer reprogramming therapy that rewrites malignant cell behavior before triggering self-destruction.
Lead program - E-ON-001 in preclinical efficacy
Senolytic Research
Safe, scalable senolytic compounds that clear senescent cells and improve healthspan today.
100+ compounds - PCC1 lead formulation
Longevity Diagnostics
AgeQuant testing platform delivering affordable biomarker panels and next-day results.
AgeQuant live - 10x cost reduction
FAQ
Frequently Asked Questions
What is partial reprogramming?01
Partial reprogramming is a technique that uses transcription factors (like the Yamanaka factors Oct4, Sox2, Klf4, and c-Myc) to trigger changes in the epigenome and cell identity, restoring cells to a more youthful state while preserving their identity and functions. Unlike full reprogramming that converts cells into stem cells, partial reprogramming rejuvenates cells without losing their specialized roles.
What is cancer reprogramming?02
Cancer reprogramming applies variants of partial reprogramming techniques to modify cancer cell behavior at the epigenetic level. This approach can reduce cancer cell invasiveness, prevent metastasis, halt uncontrolled growth, and reactivate the cells' innate self-destruct mechanisms, leading to programmed cancer cell death without harming healthy tissue.
How does 199 Biotechnologies approach cancer differently?03
Instead of trying to kill cancer cells with chemotherapy or radiation, we use cancer reprogramming. Our E-ON-001 therapy applies epigenetic reprogramming factors to modify glioblastoma cell behavior, reducing their aggressiveness and reactivating natural cell death pathways while preserving healthy brain tissue.
What is AgeQuant and how does it work?04
AgeQuant is our longevity diagnostics platform that makes comprehensive biomarker testing accessible and affordable. We test NAD+ levels, senescence markers, microplastics, and other key indicators at 10x lower cost than traditional labs.
What is Boris Djordjevic's background in biotechnology?05
Boris Djordjevic is the founder and CEO of 199 Biotechnologies, leading breakthrough research in longevity and cancer reprogramming. He founded the 199 group of companies focused on extending healthy human lifespan through cutting-edge biotechnology.
How can I access 199 Bio's treatments?06
Our cancer reprogramming therapy E-ON-001 is currently in preclinical trials. Our AgeQuant diagnostic platform is available now for comprehensive biomarker testing. We are also releasing our first senolytic polyphenol compound, which will be available for purchase online. Contact us to learn about participating in trials or accessing our current products.
What makes Procyanidin C1 special for longevity?07
Procyanidin C1 is a unique polyphenol compound we've isolated from grape seeds that has shown remarkable senolytic properties. In moderate doses, it demonstrates potency comparable to leading senolytic drugs currently in clinical trials like Dasatinib + Quercetin (D+Q), Unity Biotechnology's UBX1325, navitoclax, and fisetin. In studies, it extended lifespan by 64.2% in mice while safely clearing senescent cells that contribute to aging - but as a natural compound, it offers a potentially safer profile for regular use.
Moonshot
If we can reprogram glioblastoma - the deadliest brain cancer - we can transform how humanity treats cancer, and open epigenetic therapies for neurodegeneration, frailty, autoimmune conditions, vision loss, and skin regeneration.