Resources
Stay informed with our latest research publications and insights into the future of longevity science.
Publications
Epigenetic Reprogramming Approaches for Cancer Treatment: Progress and Challenges
199 Bio Research • 2024
Djordjevic B, et al.
Comprehensive review of partial reprogramming strategies for cancer therapy, highlighting the potential of E-ON-001 for glioblastoma treatment.
DOI: 10.199bio/2024.epi.001
AgeQuant Platform: Democratizing Longevity Diagnostics Through Digital Microfluidics
199 Bio Diagnostics • 2024
Djordjevic B, Research Team
Technical specifications and validation data for the AgeQuant platform, demonstrating 90% cost reduction in longevity biomarker testing.
DOI: 10.199bio/2024.diag.002
Emergent mechanical control of vascular morphogenesis
Science Advances • 2023
Lucitti JL, Sealock R, Buckley BK, Zhang H, Xiao L, Dudley AC, Faber JE
Blood flow-induced mechanical forces control vascular morphogenesis. We show that emergent mechanical cues regulate vessel diameter and branching patterns during development.
DOI: 10.1126/sciadv.adg9781
A Microphysiological Model of Bone Development and Regeneration
Biofabrication • 2023
Scheinpflug J, Pfeiffenberger M, Damerau A, et al.
We developed a microphysiological system that recapitulates key aspects of bone development and regeneration, enabling mechanistic studies of skeletal biology.
DOI: 10.1088/1758-5090/acd6be
Hippocampus of the APP NL-G-F mouse model of Alzheimer's disease exhibits region-specific tissue softening concomitant with elevated astrogliosis
Neuroscience • 2023
Antonovaite N, Hulshof LA, Huffels CFM, Hol EM, Wadman WJ, Iannuzzi D
In Alzheimer's disease mouse models, hippocampal tissue shows region-specific mechanical softening that correlates with increased astrogliosis, revealing biomechanical changes in neurodegeneration.
DOI: 10.1016/j.neuroscience.2023.07.028
Stromal cells regulate mechanics of tumour spheroid
Materials Today Bio • 2023
Chen S, Dong Y, Liu C
Stromal cells in the tumor microenvironment significantly alter the mechanical properties of tumor spheroids, affecting cancer progression and therapeutic response.
DOI: 10.1016/j.mtbio.2023.100726
Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration
Advanced Science • 2023
Uroz M, Garcia-Puig A, Tekeli I, et al.
The mechanical properties of endothelium and subendothelial matrix regulate cancer cell extravasation, with implications for metastasis prevention strategies.
DOI: 10.1002/advs.202206554
Microfluidic-Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease
Advanced Science • 2024
Kim S, Chung M, Jeon NL
A microfluidic platform recapitulates functional lymphatic microvasculature, enabling studies of lymphatic biology and drug screening for lymphatic disorders.
DOI: 10.1002/advs.202302903
Patient-specific colorectal-cancer-associated fibroblasts modulate tumor microenvironment mechanics
iScience • 2024
Baker AEG, Bahlmann LC, Tam RY, et al.
Patient-derived cancer-associated fibroblasts exhibit heterogeneous mechanical remodeling capabilities, influencing tumor progression and treatment response.
DOI: 10.1016/j.isci.2024.109063
Urokinase-type plasminogen activator (uPA) regulates invasion and matrix remodelling in colorectal cancer
Matrix Biology Plus • 2023
Mahmood N, Arakelian A, Khan HA, et al.
uPA expression correlates with enhanced invasion and matrix metalloproteinase activity in colorectal cancer, suggesting therapeutic targeting opportunities.
DOI: 10.1016/j.mbplus.2023.100127